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| Management number | 204569913 | Release Date | 2025/10/14 | List Price | $13.19 | Model Number | 204569913 | ||
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Advantage Multi Topical for Dogs 55.1-88 lbs Blue is a veterinarian-recommended monthly treatment formulated to provide comprehensive protection against heartworms, fleas, hookworms, roundworms, whipworms, and sarcoptic mange in medium-to-large dogs. This easy-to-apply topical solution uses a dual-active formula combining Imidacloprid and Moxidectin—powerful ingredients that kill parasites on contact and prevent reinfestation.
Perfect for dogs weighing between 55.1 to 88 pounds, Advantage Multi Blue is designed for ongoing parasite prevention while supporting your pet’s long-term health. Whether you're safeguarding your dog from deadly heartworm disease or controlling flea infestations, this topical solution ensures year-round, hassle-free protection.
Prescription items are NON-RETURNABLE and NON-REFUNDABLE.
Please note product may arrive in a Hardy Paw Pharmacy vial, manufacturer packaging is shown for reference.
Looking for the right dose of Advantage Multi for your dog’s specific weight? Explore the full range of vet-recommended flea, heartworm, and worm protection tailored to different sizes:
Each formula delivers broad-spectrum parasite protection, combining Imidacloprid and Moxidectin in weight-specific doses for optimal safety and effectiveness.
Advantage Multi (Imidacloprid + Moxidectin) offers an all-in-one approach to parasite control, eliminating the need for multiple medications.
Kills adult fleas on contact before they can lay eggs, breaking the flea life cycle
Prevents heartworm disease caused by Dirofilaria immitis
Treats and controls intestinal worms, including hookworms, roundworms, and whipworms
Effective against sarcoptic mange mites, reducing skin irritation and itching
Water-resistant formulation — remains effective even after bathing or swimming
Once-a-month topical application — easy and stress-free for both pet and owner
Understanding the core components helps identify how Advantage Multi works:
Advantage Multi Topical Solution is a once-a-month treatment that should be applied directly to your dog’s skin. Proper application ensures maximum effectiveness against parasites like fleas, heartworms, and intestinal worms.
🔒 For use only in dogs weighing 55.1–88 lbs. Not for cats or other animals.
Applying Advantage Multi for Large Dogs correctly helps maintain continuous parasite protection and minimizes any mess or irritation. Follow these veterinarian-approved steps:

Take one single-dose tube from the pack.
Hold upright and twist off the cap.
Flip the cap over and use its reverse side to pierce the seal on the tube tip.

While your dog is standing, part the fur at the base of the neck, between the shoulder blades.
Make sure the skin is clearly visible—this ensures direct skin contact.
Touch the tip of the tube to the skin and squeeze gently to dispense the entire contents in one spot only.
Avoid spreading over multiple areas or applying to broken skin.
Ensure the area remains dry for at least 24 hours.
Don’t allow your dog to lick or groom the site until fully dry.
Monitor for any signs of discomfort or skin sensitivity.
Reapply on the same date each month for uninterrupted flea, heartworm, and worm prevention.
💡 Pro Tip: Wear gloves during application and wash your hands thoroughly afterward to avoid residue contact.
While most dogs tolerate Advantage Multi well, some may experience mild reactions:
Temporary lethargy or decrease in appetite
Skin irritation at the application site (e.g., redness, itching, or hair loss)
Neurological signs like trembling or uncoordinated movement (rare)
🐾 If signs persist or worsen, consult your veterinarian immediately.
For dogs only — do not use on cats or other animals
Safe for dogs over 7 weeks of age and weighing at least 55.1 lbs
Do not apply to broken skin or if your pet is ill or debilitated
Keep out of reach of children and avoid contact with eyes and mouth
Avoid bathing your pet within 24 hours after application
Shipping Policy: HardyPaw offer all types of shipping options (Ground, Express, Priority, International) depending on the urgency of the product requirements. To know about our shipping policy in detail, click here.
Refund policy: If you face any issue with our product and want to return it, read our refund policy carefully.
Yes, Advantage Multi should be applied monthly year-round to maintain continuous protection against fleas, heartworms, and intestinal parasites, especially in warmer climates where pests remain active throughout the year.
Veterinarians should evaluate use in pregnant or lactating dogs. While studies show limited risk, Moxidectin may require caution depending on your dog's condition. Always consult your vet before starting treatment.
If ingestion occurs, contact your veterinarian or an emergency animal poison control center immediately. While rare, oral exposure may lead to drooling, vomiting, or neurological symptoms in sensitive dogs.
Advantage Multi kills fleas and internal parasites but does not repel or kill ticks. For tick control, you may need to use a separate tick-specific preventative approved by your vet alongside Advantage Multi.
Advantage Multi uses a topical formula to kill fleas and prevent heartworm, while Simparica Trio and NexGard Spectra are oral chewables that also target ticks. Choice depends on your dog’s needs and vet recommendation.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3fc1a42b-6576-4890-aa0c-5c0eb903c85a
https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/804
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